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CAS No. : 1953133-47-5

Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity.

Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-?1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) TFA is also a PI3K inhibitor and an apoptosis inducer.

Delcasertib (KAI-9803) hydrochloride is a potent and selective ?-protein kinase C (?PKC) inhibitor. Delcasertib (KAI-9803) hydrochloride could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI).

CAS No. : 1630760-75-6

BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC₅₀s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity.

CAS No. : 1305267-37-1

MSC2360844 is a potent, orally active and selective PI3K? inhibitor, with an IC₅₀ of 145 nM. MSC2360844 shows highly selective against a panel of 278 additional kinases.

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Favipiravir
(T-705)

Selectively?and?potently inhibits?the?RNA-dependent RNA polymerase?(RdRp) of RNA viruses. Shows good clinical efficacy in treating COVID-19.

Remdesivir
(GS-5734)

A nucleotide analog inhibitor of RdRp. Against SARS-CoV, MERS-CoV and Ebola virus. Effectively inhibits SARS-CoV-2 in vitro. Enters phase III trial.

Chloroquine
Phosphate

An antimalarial agent. Inhibits?autophagy?and?toll-like receptors (TLRs). Effectively inhibits?SARS-CoV-2?in vitro. FDA approved.

Hydroxychloro-
quine sulfate

An antimalarial?and anti-inflammatory agent. Inhibits?TLR7/9 signaling. Efficiently inhibits SARS-CoV-2 infection in vitro. FDA approved.

SARS-CoV-2

Compounds

Information

3CLpro

Saquinavir

An HIV Protease inhibitor. FDA approved.

Carfilzomib

An irreversible proteasome inhibitor. FDA approved.

Nelfinavir

An orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) and antiviral agent. FDA approved.

S Protein & ACE2

Bimosiamose

A nonoligosaccharide pan-selectin?inhibitor and has anti-
inflammatory effects. Phase 2.

RdRp

Zanamivir

An influenza viral neuraminidase inhibitor. FDA approved.

nsp15

Ribavirin

An antiviral agent against a broad spectrum of viruses including HCV, HIV, and RSV. FDA approved.

PLpro

Epetraborole
hydrochloride

A leucyl-tRNA synthetase (LeuRS) inhibitor. Intended for the infections caused by Gram-negative bacteria. Phase 2.

CAS No. : 1313491-22-3

VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.

WL47, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of CAV1 oligomers. WL47 shows selectivity for CAV1 over BSA, casein and HEWL. WL47 is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function.

TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC₅₀ of 10.5 ?M. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na²⁺ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells.

CAS No. : 928853-86-5

4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC₅₀ of 18 ?M. 4-MMPB has IC₅₀s of 19.5 ?M and 19.1 ?M for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.

CAS No. : 913376-84-8

SYN1143 is a potent, selective and orally active dual inhibitor of c-Met/RON, with IC₅₀s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on Lck, Tie2, Src, and BTK with IC₅₀s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated.

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